Barr body
The
condensed, inactive, single X-chromosome , appearing as a densely staining
mass, that is found in the nuclei of somatic cells of female mammals. It is
named after its discoverer, Murray Barr.
The number of Barr bodies is thus one less
than the number of X-chromosomes.
The Lyon hypothesis states that in
cells with multiple X chromosomes, all but one are inactivated during mammalian
embryogenesis
A genotypical human female has only
one Barr body per somatic cell, while a genotypical human male has none.
This happens early in embryonic development at random in mammals except in marsupials and in some
extra-embryonic tissues of some placental mammals, in which the father's X
chromosome is always deactivated.
The human abnormalities called
Kleinefelter's syndrome and Turner's syndrome both result from an unnatural
presence or absence of a Barr body.
Kleinefelter's syndrome(47XXY
genetically male but contain Barr body
and
Turner's syndrome (45X0 genetically female but
contain no Barr body .
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