Intra membranous ossification

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Intra membranous ossification

1.     Mesenchyme (fetal connective tissue membrane) contain mesenchymal sterm cell , they proliferate and condense to primary ossification centre

2.    The mesenchymal stem cells are converted into osteoblast

3.    Osteoblasts begin to secrete un-calcify bone matrix away from the blood vessel .

4.    Soon matrix become calcify and some of osteoblast tapped   in calcifies matrix become osteocyte.

5.    By this process small bone spicules are form. Bone spicules are unite with each other  and form spongy bone/ trabecular bone

6.    embryonic blood vessels grow within spaces between bone spicules and ultimately form red bone marrow which is formed by  hematopoietic stem cells, reticular cell and fibres and fibroblast and blood vessels

7.    the middle part of spongy bone remain spongy but outer and inner part of spongy bone remodel and form compact bone

8.    Outer and inner vascular mesenchyme do not take part in ossification process are converted into periosteum, endosteum or endosteal dura

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