Anatomy books

Tuesday, February 25, 2025

Difference between axon and dendrite

 Difference between axon and dendrite 

Topic 

Axon 

Dendrite 

Number 

One 

Usually more 

Nissle granule 

Absent 

Present 

Myelination 

Myelinated or unmyelinated 

Unmyelinated 

Length 

Longer 

Shorter 

Function 

Transmits nerve impulses away from the cell body to other neurons, muscles, or glands

Receives signals from other neurons and transmits them toward the cell body

Instructions for Addressing Special Figure-reading Questions BMDC Special figure checklist

 

Instructions for Addressing Special Figure-reading Questions

  • . Format of question in the card: 

         Special figure-reading question: Read the figure & Mention why you find it 'special'.

     

    B. Checklist for answering (by examinees) and for marking (by examiners).

     

    a)

    IDENTIFY the 'form' of the figure and JUSTIFY your answer.

    Examples: Photograph / Realistic (including 'semi-realistic', realistic with schematic component) diagram / Schematic diagram (i.e., simplified  shapes, not 'real'-like, using symbols etc.) / Low-power photomicrograph / High-power photomicrograph / Transmission electron micrograph / Scanning electron micrograph / Composite 3-D diagram (i.e., computer-generated complex 3-dimensional figure). 

       If a figure contains multiple ‘figure-parts’ with different ‘forms’, then the examiner needs to ask the examinee to mention the principal ‘form’. 

    0.5+0.5

    b)

    IDENTIFY the 'view' of the figure as one of the following (if there are multiple, identify each):

    Examples: Viewed from the Front/Back/Right/Left/Above/Below/Antero-superior angle/Postero-inferior angle/Antero-lateral angle/Postero-medial angle etc./ Not applicable (e.g. figures from Cell Biology & Histology). 

       If a figure contains multiple ‘views’, then the examinee should mention the principal ‘view’.  

    1

    c)

    DETERMINE whether there are any ‘sectional view(s)’ in the figure, and if so,

    SHOW.

    Examples: Sagittal section/coronal section/transverse section/longitudinal section.  

            If a figure contains multiple figure parts with different ‘sectional views’, the examinee should  mention any one ‘sectional view.’

            If there is no sectional view in the supplied figure, the examinee must say ‘There is no sectional view.’ Otherwise, he/she will not get marks.

    0.5

    d)

    IDENTIFY the ‘principal issue’ dealt with in the figure.

    Examples: development and related anomalies, detailed structure in different layers, structure-function relationships, clinical correlation of anatomy

    1

    e)

    DESCRIBE what you see in the figure.

              (Do not describe anything except what you can see).

    1.5

    f)

    MENTION why you find this figure 'special'.

    What understanding does the figure offer that would have been almost impossible to gain just by listening to someone or reading a text? 

    Examples: interconnections between different cell types of the retina (in a schematic diagram), interrelationships between podocytes and capillaries at the glomerular filtration site (in a transmission electron micrograph), 3-dimensional structural details (in a 3-D composite drawing).  

              If the figure has multiple 'special' issues, examinee must mention any two issues. 

    2

     

     

     

     

    Examples of different forms of Special Figure:

     

    Checklist for answering

    Marks

    a)

    IDENTIFY the 'form' of the figure and JUSTIFY your answer.

    Examples: Photograph / Realistic (including 'semi-realistic', realistic with schematic component) diagram / Schematic diagram (i.e., simplified  shapes, not 'real'-like, using symbols etc.) / Low-power photomicrograph / High-power photomicrograph / Transmission electron micrograph / Scanning electron micrograph / Composite 3-D diagram (i.e., computer-generated complex 3-dimensional figure). 

       If a figure contains multiple ‘figure-parts’ with different ‘forms’, then the examiner needs to ask the examinee to mention the principal ‘form’. 

    0.5+0.5

     

    1.    Photograph

    A figure that is a reproduction of an image created using a photographic camera is termed a 'photograph.'

    Mode of answer: This figure is captured by a photographic camera from real structures, viscera, models, skeletons, bodies, prosected specimens, etc. (not taken from other pictures/images, such as diagnostic images or microscopic images).

     




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Microtubule: Justify- microtubule is essential for cell division

Microtubule: Justify- microtubule is essential for cell division 

Microtubules: Essential for Cell Division

Microtubules play a critical role in mitosis and meiosis by:

  1. Forming the Mitotic Spindle – Aligns and separates chromosomes accurately.

  2. Chromosome Movement – Kinetochore microtubules pull chromosomes to opposite poles.

Without microtubules, chromosome segregation fails, leading to cell division defects.


Cell membrane: Justify the role of cell membrane in keeping the ion content of cytoplasm constant

Cell membrane: Justify the role of cell membrane in keeping the ion content of cytoplasm constant. 

Cell Membrane: Role in Maintaining Ion Content of Cytoplasm

It regulates ion balance through selective permeability and active transport mechanisms:

  1. Selective Permeability – Controls the entry and exit of ions via ion channels.

  2. Active Transport – Uses ATP-driven pumps (e.g., Na⁺/K⁺ pump) to maintain ionic gradients.

  3. Endocytosis & Exocytosis – Helps in bulk transport of ions and molecules.

This ensures homeostasis, preventing drastic changes in cytoplasmic ion concentration, which is crucial for cell function.


Ribosomes: Justify presence of both attached & free ribosome in cytoplasm.

 Ribosomes: Justify presence of both attached & free ribosome in cytoplasm. 


Ribosomes exist in two forms in the cytoplasm: free ribosomes and attached (bound) ribosomes, each serving distinct functions:

  1. Free Ribosomes: Float freely in the cytoplasm.

Function: Synthesize proteins that function within the cytoplasm (e.g., enzymes for metabolism).

Attached Ribosomes:

  • Bound to the rough endoplasmic reticulum (RER).


Function: Protein Synthesis – Produces proteins for secretion, plasma membrane, and organelles (e.g., lysosomes).

Transport – Sends proteins to the Golgi apparatus for further processing and distribution.




Nucleus: Justify the presence of pores in the nuclear membrane

Nucleus: Justify the presence of pores in the nuclear membrane.

Nuclear pores regulate material exchange between the nucleus and cytoplasm while maintaining nuclear integrity.

  • Transport: Controls movement of RNA, proteins, and molecules.

  • mRNA Export: Allows mRNA to exit for protein synthesis.

  • Waste Removal: Expels non-functional RNA and waste.

Thus, nuclear pores ensure controlled exchange and protection, vital for cell function.

Structure of Nuclear Pores

Nuclear pores are large protein complexes embedded in the nuclear envelope, regulating the exchange of materials between the nucleus and cytoplasm.

Key Structural Features:

🔹 Nuclear Pore Complex (NPC) – A massive, basket-like structure made of ~30 different nucleoporins (Nups).

1. Central Framework (Core Scaffold)

  • Forms the main structural ring spanning the nuclear envelope.
  • Composed of Y-complex nucleoporins, providing stability.

2. Cytoplasmic Ring & Cytoplasmic Filaments

  • Faces the cytoplasm.
  • Filaments extend outward, helping in cargo recognition and transport.

3. Nuclear Ring & Nuclear Basket

  • Faces the nucleus.
  • Basket-like structure assists in the export of RNAs and proteins.

4. Transport Channel (Central Pore)

  • FG-Nucleoporins (rich in Phenylalanine-Glycine repeats) line the channel.
  • Creates a selective barrier allowing small molecules to diffuse and large molecules (like RNA & proteins) to pass via active transport.

Function:

Regulates RNA, ribosomal subunits, and proteins transport.
Maintains nuclear compartment integrity.
Controls signal-dependent transport via importins/exportins. 




Cytoskeleton: Justify the term ‘cytoskeleton’ in relation to its functions

Cytoskeleton: Justify the term ‘cytoskeleton’ in relation to its functions. 

The cytoskeleton is a dynamic network of microfilaments, intermediate filaments, and microtubules that provides structural support to the cell, much like a skeleton does for the body.

  • Support – Maintains cell shape and strength.

    • Microfilaments: Ensure shape and flexibility.

    • Intermediate Filaments: Provide strength and prevent deformation.

    • Microtubules: Act as scaffolding, resisting compression.

Together, they function as the cell’s skeleton, maintaining its structure and stability.

Cytoskeletal Elements: Must-Know Filaments

1. Microfilaments (Actin Filaments) – Thin & Flexible

  • Actin → Main protein, supports cell shape, movement, and intracellular transport.
  • Fimbrin & Fascin → Bundling proteins in microvilli and filopodia.
  • Filamin → Cross-links actin for gel-like networks.
  • Spectrin → Supports plasma membrane (e.g., in RBCs).
  • Dystrophin → Links actin to muscle cell membranes (deficient in Duchenne muscular dystrophy).

2. Intermediate Filaments – Strong & Durable

  • Keratins → Found in epithelial cells, skin, hair, and nails.
  • Vimentin → Present in mesenchymal cells (fibroblasts, endothelial cells).
  • Desmin → Found in muscle cells, supports sarcomere structure.
  • Neurofilaments (NF-L, NF-M, NF-H) → Provide support in neurons.
  • Glial Fibrillary Acidic Protein (GFAP) → Found in astrocytes and glial cells.
  • Lamin (A, B, C) → Nuclear lamina, maintains nuclear shape.

3. Microtubules – Rigid & Dynamic

  • Tubulin (α & β-tubulin) → Forms the basic structure of microtubules.
  • Dynein → Moves cargo towards the minus end (retrograde transport, e.g., in cilia and flagella).
  • Kinesin → Moves cargo towards the plus end (anterograde transport).
  • Tau → Stabilizes microtubules (abnormal in Alzheimer’s disease).
  • MAPs (Microtubule-Associated Proteins) → Regulate microtubule stability and dynamics.
  • https://rkmri.co/SeAley5S5yEl/