Goosecoid gene

 Goosecoid gene 

GSC (Goosecoid Homeobox) gene is a Protein Coding gene.

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The GSC gene defines neural-crest cell-fate specification and contributes to dorsal - ventral patterning

The homeobox gene goosecoid is one of the first genes expressed in the organizer region of vertebrates and specifies future dorsal regions along the anterior/posterior axis of the embryo. this gene is expressed in embryos of all ages and localization on one side of the embryoblast In embryos collected at day 13 of pregnancy gsc expression was localised anterior to the primitive streak.

In embryos collected at day 13 of pregnancy gsc expression was localised anterior to the primitive streak.

Ectopic expression of gsc mRNA in ventral blastomeres as well as overexpression of gsc in dorsal blastomeres leads to cell movement toward the anterior of the embryo. Diseases associated with GSC include Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities and Maturity-Onset Diabetes Of The Young, Due to its role as a transcription factor in cell migration during embryonic development, GSC has been looked into as a potential role-player in cancer development and metastasis, since embryonic development and cancer development share similar characteristics. 

Major categories of EMP stimuli and markers involved in EMP. The dynamics of the epithelial – mesenchymal spectrum can be induced by five major stimulii (hypoxia, immuno-modulators, mechanical stress, altered ECM, and chemotherapeutics), which involve changes in various functional and morphological states and enlisted markers across the spectrum of epithelial–mesenchymal plasticity. ECM, extracellular matrix.