Climbing fiber of cerebellum

Climbing fiber of cerebellum 

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They are the terminal fibers of the olivocerebellar tracts

One climbing fiber makes synaptic contact with

1-10  purkinje neuron

Climbing fiber arises from

·         the inferior olivary nucleus located in the medulla oblongata

They passes through the granular layer and purkinje layer and terminate into  the molecular layer

These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle

These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory postsynaptic potential (EPSP) in Purkinje cells

 In this way climbing fibers (CFs) perform a central role in motor behaviors.

They influence 

·         Motor timing.

·         the control & coordination of movements

·         They contribute to sensory processing and cognitive tasks likely by encoding the timing of sensory input independently of attention or awareness

Climbing fibers cross the midline in the brain stem, enter the cerebellum through the inferior cerebellar peduncle, and terminate contralaterally within the cerebellum.

In the central nervous system, these fibers are able to undergo remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation.

This kind of injury-induced sprouting has been shown to need the growth associated protein GAP-43

Climbing fiber cannot have rosettes

A single purkinje neuron makes synaptic contact with only one climbing fiber

Climbing fiber > purkinje fiber