Mossy fiber of cerebellum

Mossy fiber of cerebellum 

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They are the termical fibers of all other cerebellar afferent tract

One mossy fiber makes synaptic contact with 1000 purkinje neuron through granule cells of cerebellum

Mossy fiber arises from many sources

·         cerebral cortex ( largest),

·         the vestibular nerve and nuclei

·         the spinal cord ,

·         the reticular formation  

            feedback from deep cerebellar nuclei

Mossy fibers from the vestibular ganglion are the first mossy fibers to arrive in the cerebellum

They terminate in the granular layer of the cortex within the glomeruli

Axons of mossy fiber enter the cerebellum via the superior , middle and inferior cerebellar peduncles

They serve as inhibitory interneuron , they influence the degree of purkinje cell excitation

They  modify muscle activity through the motor control areas of the brain stem and cerebral cortex

Depending on the source of the mossy fibers, their termination within the cerebellum can be predominantly ipsilateral or contralateral and is restricted to particular lobules.

Keratan sulfate proteoglycan phosphacan regulates mossy fiber outgrowth and regeneration

Each mossy fiber can have up to 50 rosettes

unlike climbing fibers, mossy fibers DO NOT go directly to the Purkinje cell.

Mossy fiber > granule cell > purkinje fiber