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Monday, April 29, 2024

General embryology: Decidua : the pregnant endometrium

 

Decidua

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Decidua means gravid endometrium.

Decidualization / Decidua reaction

·         Stromal cells of the endometrium become polyhedral and loaded with glycogen and lipids

·         Stromal cells begin to secrete cytokines, growth factors, and proteins like IGFBP1 and prolactin along with extracellular matrix (ECM) proteins such as fibronectin and laminin. The increased production of these ECM proteins turns the endometrium into the dense structure known as the decidua,

·         Presence of decidual white blood cells (leukocytes),

·         intercellular spaces are filled with extravasate

·         the tissues is edematous

At first it occur at the site of implantation but soon spread throughout the endometrium.

Parts of decidua: it is divided into three parts

1.       Decidua basalis :parts of decidua deep to the developing embryo which contributes to the development of placenta

2.       Decidua capsularis :part of decidua which surround the embryo and it is separated from the uterine cavity

3.       Decidua parietalis :rest of the decidua excluding decidua basalis and decidua capsularis

 

 

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