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Sunday, April 28, 2024

General anatomy of muscular system

 

Muscular system 

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Muscles are primarily designed for movement

Types of muscles of human body :

  1. Skeletal muscle ( has bony attachment, related to skeleton)
  2. Cardiac muscle ( muscles of heart, myocardium is formed by cardiac muscle)
  3. Smooth muscle( muscles of viscera)

Histological classification of muscle:

  1. Striated muscle:(cross pattern seen within the muscle cells)   skeletal muscle, and cardiac muscle
  2. Non striated muscle: (no cross pattern within the muscle cells) Smooth muscles

Functional classification of muscles:

  1. Voluntary muscles: skeletal muscle
  2. Involuntary muscles: cardiac and smooth muscle

Skeletal muscle:

Parts of a skeletal muscle: each muscle of body has two part

1.       a fleshy part

2.      a fibrous part : (ex: tendon or aponeurosis)

Features of skeletal muscle:

  1. each skeletal muscle has at least two attachment sites – origin (proximal attachment )

      and insertion (distal attachment )

  1. each skeletal muscle has to cross at least one joint
  2. Skeletal Muscle can move particular part of body
  3. Every muscle can relax (increase the length of muscle) & contract (shortening of muscle )
  4. skeletal muscle situated in front of a joint and also behind the joint

Q. What do you mean by Origin and insertion of a skeletal muscle?

Each muscle has two ends which attached with bone, cartilage and other structure.

During movement one end is fixed and other end is move.

Fixed end usually consider as origin of a muscle and

Movable end consider as insertion of a muscle.

But both end of muscle may move or fixed

Origin: the end of muscle which is situated near the trunk is known as origin

Insertion: the end of muscle which is situated far from the trunk is known as insertion

 Classification of skeletal muscles

i)      According to the colour skeletal muscles are two types :

Red muscle

      Less cross-striation and large number of mitochondria and myo-haemoglobin

      Contraction is slow but more sustained

      Examples: antigravity muscle of the trunk, brachialis, soleus 

 

White muscle

      More cross-striation and less number of mitochondria and myo-haemoglobin

      Contraction is rapid but less sustained

      Examples: biceps brachii

 

ii)                 Morphological classification of skeletal muscle: (According to the direction of the muscle fibers present  in fleshy part of muscle)

 

  1. Parallel 2.Triagular 3. Pennate 4. Spiral  5. Cruciate

1. Parallel :

 

 

 

 

Quadrilateral :

(thyrohyoid) 

 

Long and strap like :

 sartorius

Strap with tendinous

 intersections :

rectus abdominis

Fusiform: Gastrocnimius

 

 

2. Triangular:  Fibres are oblique to the line of pull Temporalis

 

 

5. Cruciate :sternocleidomastoid,

 messeter 

4. Spiral: Sternocostal fibres of pectoralis major and latissimus dorsi

 

3. Pennate

Unipennate : soleus

Bipennate rectus femoris

Multipennate : deltoid

Circumpennate : tibialis anterior

 

What is contraction of muscle?

50-55% shortening of fleshy part of a muscle from its resting length is known as contraction of muscle 

Structural organization of a skeletal muscle

Muscle: is formed by several muscle bundles and surrounded by a connective tissue layer known epimysium

 

Muscle bundle: is formed by several muscle fibers and surrounded by a connective tissue layer known perimysium

 

Muscle fiber or muscle cell is surrounded by a connective tissue layer known endomysium.

Each muscle fiber is formed by myofibrils

Myofibrils: are thread like structures (situated along the long axis of the entire length of muscle fibres. ) which are formed by myofilaments( myosin and actin) .

 Each myofibril contain a dark area known as A band and  a light  area known as I band 

Myofilaments: are longitudinally oriented protein filaments lies within each myofibrils . They contain  two types of protein filaments

thick filament: myosin and

thin filament –actin, tropomyosin, troponin

Cross striation.: Due to particular arrangement of myofilament, some areas of (skeletal / cardiac) muscle fibres appear dark and some area white which is known as cross striation.

Dark area of cross striation

Light area of cross striation .

Dark area known as A band: 

Light area known as I band

A band contains whole myosin filament and part of actin filament.

I band contain part of actin filament

A band  contain H band:

this area contain only myosin filament but no actin filament (less dark area)

H band contain M line :

Myosin filament link together transversely. this is represented by M line 

I band contain Z line : each I band contain a central Z line. Actin filaments are transversely attached with each other 

 

 

 

 

Each muscle fiber is an individual muscle cell and consists of following parts

Sarcolemma: cell membrane of muscle fibre

Sarcoplasm : cytoplasm of muscle fiber

Sarcoplasmic reticulum : smooth surfaced endoplasmic reticulum which surrounds the myofibrils

Nuclei: multiple peripherally placed nuclei.

(In embryo it is situated in the center but later pushed to periphery otherwise they interrupted the contractile mechanism of muscle fiber)  

Mitochondria: they are situated in rows  between the myofibrils 

Myofilament :

Form by thick filament : myosin                                 

Thin filament : actin, troponin , tropomyosin

Neuromuscular junction connects the nervous system to the muscular system via synapses.

Terminal end of axon (process of neuron) connect with sarcolemma (cell membrane of muscle cells) So action potential of nerve transmitted to muscle and a contraction (shortening of length of muscle) is beginning.

 Q: What is sarcomere?

Ans : Sarcomere: The segment of a myofibril between two adjacent Z lines, representing the contractile (functional) unit of striated muscle.

Muscle tone: it means a partial state of contraction of a muscle to maintain a constant muscle length. A muscle is not completely relaxed even in resting condition.

Regeneration of muscles:

Skeletal muscle: usually do not regenerate if part of muscle fiber is destroyed moderate regeneration is possible.

Cardiac muscle: regeneration is not possible

Smooth muscle: regeneration is possible

Mechanism of contraction: In short :

Action potential of nerve ending causes –

 releases Ca++ that results release of Acetylcholine (ACh)

---ACh binds with the sarcolemma

---so, Muscle Fiber Action Potential initiated

through T tubule action potential passage

--- sarcoplasmic reticulum release Ca ++ ions

– Calcium ions bind to the troponin on the thin filament

—roll the tropomyosin deeper aspect and exposed actin (which  allow actin myosin interaction)

 – ATP bind with myosin heads and develop affinity for actin

–myosin bind with actin

–causes Movement of myosin head toward the M line

  overriding of myosin and actin filament is result- initiates contraction.

Ca++ ion activate ATPase  which rapidly hydrolyses ATP and disconnect myosin head from actin

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