Weibel-Palade Bodies of endothelium of blood vessel

 

Weibel-Palade Bodies of endothelium of blood vessel 

Weibel-Palade bodies are specialized, elongated storage granules found in the endothelial cells of blood vessels. They primarily contain:

• Von Willebrand Factor (vWF): Essential for platelet adhesion and blood clotting.
• P-selectin: A cell adhesion molecule involved in inflammation and leukocyte recruitment.

These granules play a crucial role in hemostasis and immune responses by releasing their contents in response to vascular injury or inflammatory stimuli.

This spiral muscle architecture, refined through evolution, enables the heart to maintain efficient circulation with minimal energy loss, ensuring optimal cardiac function.

Weibel-Palade bodies ( in all arteries except meta artrioles ) membrane-bound inclusions, 0.1 µm in diameter and 3 µm long, that have a dense matrix housing tubular elements containing the glycoprotein vWF (von Willebrand factor) as well as tissue factor and P[1]selectin. The vWF facilitates the coagulation of platelets during clot formation. Tissue factor enhances the process of coagulation, and P-selectin induces leukocytes to leave the bloodstream, to enter the connective tissue paces, and to function in the immune process. CLINICAL CORRELATIONS Patients with von Willebrand disease, an inherited disorder that results in impaired adhesion of platelets, have prolonged coagulation times and excessive bleeding At an injury site.